MB ARDESHIR LARIJANI; H RAMIN; A LASHKARI; P SHOUSHTARIZADEH; V HAGHPANAH; SM TAVANGAR
Volume 14, Issue 1 , March and April 2007, , Pages 32-37
Abstract
Background and Purpose: Surviving is one of the eight members of the human inhibitors of apoptosis (IAP), which appears to be differentially expressed in cancer cells. This study was conducted to evaluate the clinical usefulness of survivin immunostaining to distinguish between follicular adenoma and ...
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Background and Purpose: Surviving is one of the eight members of the human inhibitors of apoptosis (IAP), which appears to be differentially expressed in cancer cells. This study was conducted to evaluate the clinical usefulness of survivin immunostaining to distinguish between follicular adenoma and carcinoma of thyroid.
Methods and Materials: This study was a cross-sectional descriptive-analytical research. The study population was tissue samples from surgery patients at Shariati Hospital in Tehran, Iran. All samples were studied through immunohistochemical staining for surviving.
Results: Surviving expression was significantly (p
MB ARDESHIR LARIJANI; SM TAVANGAR; AR SHAFAHI; A LASHKARI; M RASOULINEZHAD; R HESHMAT; M IZADI; V HAGHPANAH; SH AFHAMI; M MOHRAZ
Volume 13, Issue 4 , January and February 2007, , Pages 166-171
Abstract
Background and Purpose: A wide spectrum of endocrine abnormalities including thyroid dysfunction has been observed in HIV-infected patients with different results. This study was conducted to determine the frequency of thyroid dysfunction and to identify factors affecting the development of hypothyroidism ...
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Background and Purpose: A wide spectrum of endocrine abnormalities including thyroid dysfunction has been observed in HIV-infected patients with different results. This study was conducted to determine the frequency of thyroid dysfunction and to identify factors affecting the development of hypothyroidism in HIV-infected patients.
Methods and Materials: Free T4, FT3, TSH, and thyroglobulin levels of 88 HIV-infected patients receiving care at UT counseling center for Behavioral Disorders in Tehran, an out patient referral center, were measured and data on their age, sex, body weight, BMI, history of opium and injection addictions, duration of HIV infection, disease stage, history of opportunistic infection or malignancy, CD4 cell count, antiretroviral treatment with antiretroviral drugs (HAART), receipt of other drugs (TMP-SMX, antituberculosis drugs, and steroids), and hepatitis C virus Co-infection were collected. Inclusion of the subjects was simply random.
Results:17% of subjects had hypothyroidism; 1.1% had overt hypothyroidism; 2.3% subclinical hypothyroidism and 13.6% had low FT4 levels. The multivariate analysis showed that none of the studied factors were associated with the development of hypothyroidism.
Conclusion: As none of the above-mentioned factors are not associated with the development of hypothyroidism, hypothyroidism should be considered in HIV-infected patients.
MB ARDESHIR LARIJANI; R MALEKZADEH; V HAGHPANAH; B SOLEYMANPOUR; R HESHMAT; SM TAVANGAR
Volume 13, Issue 4 , January and February 2007, , Pages 190-195
Abstract
Background and Purpose: This study was intended to record the number of endocrine cancer in four provinces of Iran.
Methods and Materials: Patients in each province were classified according to their age, gender, sex, and tumor characteristics (site, morphology and behavior). The obtained data were ...
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Background and Purpose: This study was intended to record the number of endocrine cancer in four provinces of Iran.
Methods and Materials: Patients in each province were classified according to their age, gender, sex, and tumor characteristics (site, morphology and behavior). The obtained data were coded according to ICD-O. High- risk age was calculated for each province and the results presented as incidence rates by sex, age, age- specific rates and ASR per 100,000 person – years using standard statistical methods to the world population.
Results: Out of 319 cases of primary endocrine cancers found and recorded, 313 cases were thyroid carcinoma and 6 cases were adrensal cancers. In thyroid carcinoma group, the share of Papillary, follicular, medullary and anaplastic carcinomas accounted for 82.7%, 8.6%, 7.0% and 1.6% respectively. Also, the ASR of thyroid carcinoma for total, male and female cases were 1.289, 0.627 and 1.59 respectively. The highest incidence rate of the thyroid carcinoma was found in Kerman with the ASR of 1.643 for both genders and the lowest rate in Golestan with the ASR of 0.735. Mean age of patients was 43.9 years (SD=15.90) and their age ranged from 3 to 8 years. This figure for males was 45.21 (± 17.13) and for females 43.49 (±15.51) (P= 0.41). Also, the female - male ratio was 3.1 to 1. In adrenal cases (n=6), 4 cases (66.7%) had neuroblastoma and 2 cases were pheochromocytoma (33.3%). The mean diagnosis age was 16.17 (± 7.05) years for the whole population of cases; 13.00 (±3.46) years for males and 19.33 (±9.07) for females (P=0.32)
Conclusion: Iran was considered as an endemic iodine-deficient region until fairly recently. However, iodinization of salt started 12 years ago and since then, this increase has caused an increase in the incidence of papillary cancer, compared to other thyroid carcinomas; its frequency and distribution closely correspond to the observed profile in areas with high iodine consumption.
SM TAVANGAR; MB ARDESHIR LARIJANI; A MAHTA; V HAGHPANAH; A LASHKARI; R HESHMAT
Volume 13, Issue 2 , July and August 2006, , Pages 99-104
Abstract
Background and Purpose: Pituitary adenomas without clinically active hypertension are termed as non-functioning adenoma (NFPA). These tumors represent about one quarter of all pituitary tumors. Immunohistochemical methods are the gold standard methods of identifying them. The Ki-67 is a nuclear antigen ...
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Background and Purpose: Pituitary adenomas without clinically active hypertension are termed as non-functioning adenoma (NFPA). These tumors represent about one quarter of all pituitary tumors. Immunohistochemical methods are the gold standard methods of identifying them. The Ki-67 is a nuclear antigen detected by the monoclonal antibody MIB-1, whose labeling index (LI) is considered as a marker of normal and abnormal cell proliferation.
Methods and Materials: In this clinicopathological study, 85 cases of NFPAs were analyzed immunohistochemically.
Results: MIB-1 LI was measured in all surgical specimens, which was higher than 5% only in 5 cases. Also, 18 cases were immunoactive to one or two adenohypophysial hormones.
Conclusion: NFPAs comprise several pathologically different types of tumors, some of which are potentially hormone producing tumors. However, probable defects in hormone secretion may be the cause of not increasing the adenohypophysial hormone levels in the serum and consequent syndromes.
SM TAVANGAR; MB ARDESHIR LARIJANI; AR SHOJAEE; H MAHMOUDZADEH; V HAGHPANAH; A SOLEYMANI; SO ABBASS
Volume 13, Issue 2 , July and August 2006, , Pages 105-107
Abstract
Background and Purpose: Spinal cord compression due to metastasis, as the initial presentation of follicular thyroid carcinoma, is quite uncommon. In this article, we report one case of well-differentiated thyroid carcinoma which has led to the compression of the spinal cord.
The patient: The case we ...
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Background and Purpose: Spinal cord compression due to metastasis, as the initial presentation of follicular thyroid carcinoma, is quite uncommon. In this article, we report one case of well-differentiated thyroid carcinoma which has led to the compression of the spinal cord.
The patient: The case we report here is a man of 53 years old, with increasing neck pain, paraplegia and urinary incontinence. Magnetic resonance imaging of the neck revealed a mass which had destructed C5 with extension to C6.
Conclusion: Histopathology examination demonstrated the metastasis of a well-differentiated follicular carcinoma of thyroid. Therefore, the metastatic lesion of the thyroid carcinoma should be considered in any case of spinal cord compression.